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Landmark trials, including CREDENCE, DAPA-CKD, EMPA-KIDNEY, and FLOW, have demonstrated their efficacy in preserving kidney function and reducing adverse outcomes

PubMedPMC 57

Retatrutide is a novel triple-agonist peptide developed by Eli Lilly, targeting GIP, GLP-1, and glucagon receptors, showing significant promise in clinical trials for obesity and type 2 diabetes due to its potent effects on appetite, energy expenditure, and glycemic control

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These can include severe gastrointestinal problems like nausea or vomiting, and in rare cases, pancreatitis

Until now the tests with exendin-4 had only been done in mice and the company was unsure what would happen when it was given to humans