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The peptide activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in a dose-dependent manner, leading to nuclear translocation and activation of transcription factors including c-Fos, c-Jun, and early growth response-1 (Egr-1) that drive expression of genes involved in cell growth, migration, and angiogenesis

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Higher DSIP levels correlate with better mental resilience, especially in individuals suffering from depression

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Rather than flooding synapses with a single neurotransmitter, it modulates the balance between serotonin, dopamine, and norepinephrine, nudging each toward optimal levels rather than artificially elevating one at the expense of others

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