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Evidence at present favours chronic inflammation as a trigger for chronic insulin insensitivity, rather than the reverse situation.

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[DOI] [PubMed] [Google Scholar] 156.Erickson JC, Clegg KE, Palmiter RD

NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation