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The systemic copper load from topical application is minimal, so there's generally no concern about combining routes

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It has a population mean clearance of 0.061 L/h

[DOI] [PubMed] [Google Scholar] 132.Wilding J.P.H., Batterham R.L., Calanna S., Davies M., Van Gaal L.F., Lingvay I., McGowan B.M., Rosenstock J., Tran M.T.D., Wadden T.A., et al