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10.1093/nar/gki856 18 BartekovaM.BarancikM.FerenczyovaK.DhallaN

The precise mechanism of kidney-protective effects of GLP-1 RAs still remains elusive, but likely include direct kidney actions such as inducing natriuresis through NHE3 inhibition in the proximal tubules, suppressing the intrarenal renin-angiotensin system, ameliorating kidney ischemia/hypoxia [63, 64]

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It also resulted in reduced activation of the inflammatory pathway and decreased cytokine expression [77]

It also helps modulate GABA, a calming neurotransmitter that prevents overstimulation in the brain

Hoevenaars FPM, Wopereis S, Plugues M, La Terra P, Batchnarova N