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In addition to transposons, previous studies have reported that endosymbiosis may have also played an important role in the reduction of protein size in plant genomes 37, 43, 44 This would have been due to the post endosymbiosis acquisition of thousands of genes from the chloroplast, since cyanobacterial proteins are smaller than eukaryotic proteins and cyanobacteria are the ancestors of plastids 37, 45

Microbes are vital contributors to the host metabolism, considering that numerous important components, such as vitamin K, indoles, gamma amino butyric acid, folate, and short-chained fatty acids (SCFAs), are produced by microbiota (Brown and Hazen, 2018)

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Most manufacturers, including us, state that unopened vials can be safely stored at controlled room temperature (around 20C to 25C or 68F to 77F)

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