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The American Diabetes Association has issued strong warnings against using non-FDA-approved compounded GLP-1 and dual GIP/GLP-1 products, and the same caution applies even more strongly to investigational medications like retatrutide

We discuss the most appropriate approach at consultation

Importantly, tirzepatide is not metabolized through the cytochrome P450 enzyme system, and renal impairment has minimal impact on its exposure

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The SRM analysis was performed using SCIEX 5500 QTRAP and Exion LC (AB SCIEX, Foster City, CA, USA)

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