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Another meta-analysis including children ages 6-17 with obesity, type 2 diabetes, or prediabetes found that GLP-1s significantly reduced A1C and weight compared to placebo

Modulation of endothelial dysfunction may be also implicated in the amelioration of renal function observed even in the absence of diabetes [59]

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Similarly, whilst abdominal discomfort may occur with GLP-1 receptor agonists, severe or persistent pain should not be dismissed as a simple medication side effect