Rats were recorded and afterwards assessed (slow-down video) for forelimb function impairment
L.LetavernierE.et al (2010)
These limitations may be partially overcome by conditional reprogramming with the Rho associated coiled-coil containing protein kinase inhibitor, Y27632, or bone morphogenetic protein/transforming growth factor, beta 1 antagonists that repress differentiation and extend culture life
doi:10.1042/CS20100597 Tipton KD, Rasmussen BB, Miller SL, et al
[15] So, it seems that a huge part of berberine's overall benefit comes from restoring mitochondrial function a common theme among the best nutritional supplements
They can block pro-inflammatory signals like TNF or interleukin pathways by competing for receptor binding