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In the second study, the authors reported a significant reduction of total testosterone and LH in only metformin group, while treatment with liraglutide led to a significant LH increase, without differences in FG score between the two groups [58]

doi: 10.1056/NEJMoa2500969

"And, you know, that's not an evidence-based practice

Higher resting metabolic rate

Nevertheless, there is no doubt that GLP-1 interacts with vagal afferent neurons and the arcuate nucleus of the hypothalamus, critical components of the gut-brain axis that connect peripheral metabolic signals to the central nervous system [10]

These options are intended for supervised use within a structured care model