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388 Knockout of 2,6-sialyltransferase suppresses the polarization of CD4 + T cells to Th17 cells while promoting their polarization to Treg cells, inhibiting the secretion of IL-17a, and alleviating UC symptoms

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While the second mutant is missing the first three amino acids of IGF-1 (IGF-1 DES) and was named knock-in D (KID)