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In early phase 2a trials, it effectively improved glycemic control, increased post-meal insulin levels, and facilitated weight loss in participants with obesity and patients with T2DM [83]

There is also a separate safety question, distinct from efficacy: retatrutide raises resting heart rate by 5 to 10 beats per minute, which has not yet been characterised in patients who already have heart failure or irregular heartbeats

Looking ahead, employers may continue to face the competing pressures of employee demand for GLP-1 drugs and concerns about costs

Discuss the tradeoffs honestly with your provider