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A specific substrate from rabbit cerebellum for guanosine 3 : 5 -monophosphate-dependent protein kinase

This bidirectional effect, scientists call it buffering , is probably the key to its protective profile

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Similar to scrapie, -synuclein pathology spreads in the peripheral and enteric nervous systems, then to CNS, whereas Alzheimers tau pathology propagates within the CNS only, beginning in the brainstem then involving cortical areas in a characteristic pattern (Braak and Del Tredici, 2016