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Notably, sepsis is an acute systemic infection triggered by the invasion of pathogenic bacteria into the blood circulation and the production of toxins

G2019S is the most common variant in Europe and North America, accounting for 4% of familial PD and 1% of sporadic PD (Healy et al., 2008), while in Asia this variant is rare but prominent allelic heterogeneity was observed (Foo et al., 2017, 2020)

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Mitochondrial ROS inactivate redox-sensitive tyrosine phosphatase PTP1B, enhancing TGF- receptor phosphorylation [381]