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More recently, the semaglutide STEP 3 study, which compared 2.4mg of once weekly semaglutide to placebo and included intensive behavioral therapy in both groups (hypocaloric diet plus exercise), reported 5% weight loss in 87% of those treated with semaglutide and 48% of those treated with placebo lost 5% body weight, and 10% weight loss in 75.3% treated with semaglutide and 27% treated with placebo (14)
GLP-1 agonists increase satiety and reduce appetite, leading some patients to consume less fluid inadvertently
The risk of gastric paralysis is small
Alkhatib M, Almasri N, Alshwayyat S, et al
The article says they were originally developed for type 2 diabetes and expanded into weight management as clinical evidence accumulated on their effects on satiety and metabolic function
J Pineal Res 56(1):97106 Parzych KR, Klionsky DJ (2014) An overview of autophagy: morphology, mechanism, and regulation
