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The plasma concentrations of 7,8-DHF followed a two-compartment model where there was an initial rapid distribution occurred within 30 min of the IP injection, followed by a slower terminal phase with a terminal half-life of 1 h (Figure 5A)

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They also contribute to metabolic activity related to energy production and nutrient utilization

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Cancer 133 UekiT.FujimotoJ.SuzukiT.YamamotoH.OkamotoE

Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels