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Johnson, M., Wang, Q., & Silva, R

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PD is characterized by mitochondrial deficiency-linked lactylation in dopaminergic neurons (Han et al., 2024)

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Within the small cavities (follicles) of the thyroid, tyrosine (an amino acid that serves as the building block for thyroid hormone production) combines with iodide through a process called iodination, to create several thyroid hormones: T1, T2, T3, T4

These analyses confirm all acetylation sites present in flexible loop regions, i.e., Lys78, Lys94, Lys98, Lys103 and Lys106, are deacetylated in an NAD + -dependent manner by the human sirtuins, while the sites not solvent-exposed orienting to the core of SnCE1 or present in areas of profound secondary structure, i.e., Lys209, Lys231 and Lys248, are not deacetylated (Figs