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Retrieved 3 July 2023

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Conversely, constipation has been shown to persist longer than other GI side effects and is more frequently observed in obesity-focused studies

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I dont have the scientific evidence to prove it (yet), but as I look at the extreme side effects many people experience (nausea, fainting, pancreatitis, dampening reward systems, gas, etc.) its clear to me that the drugs are fighting the natural order of how our bodies function and I have major concerns for how this will impact us in ways we dont yet see