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DOI:10.1002/rcm.3106

However, post-cholecystectomy patients may experience more diarrhea or loose stools because continuous bile flow interacts with tirzepatide's gastric-slowing effects

The main disadvantages include potential gastrointestinal upset (nausea, vomiting, diarrhoea), particularly when starting oral supplements

contraindicated in pregnancy due to teratogenicity risk Naltrexone-bupropion (Contrave): Opioid antagonist and antidepressant combination producing 5-6% weight loss

doi: 10.3389/fphar.2025.1551843 Received 26 December 2024 Accepted 09 June 2025 Published 02 July 2025 Volume 16 - 2025 Edited by Ting Shen, Yangzhou University, China Reviewed by Shuo Yuan, University of Virginia, United States Yan Hu, Second Affiliated Hospital of Dalian Medical University, China Updates Copyright 2025 Mao, Huang, Li, Sun, Zhang, Cheng, Zeng, Lei, Wang and Yao

This ensures that the nutrients actually reach your cells, where they can support your energy, immunity, and ageing process