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The magnitude varies significantly between individuals: STEP 4 Trial : Participants who stopped semaglutide after 20 weeks regained approximately 7% body weight over next 48 weeks (compared to losing an additional 8% who continued medication) Real-World Studies : Variable outcomes

Research also shows that gastrointestinal symptoms and other side effects are less likely to occur

Common side effects of GLP-1 treatments whether Semaglutide tablets, Tirzepatide injections, or other forms may include nausea, constipation, fatigue, or decreased appetite

Systematic Reviews and Meta-analyses Four meta-analyses analyzed the metabolic outcomes of the combined therapy

Research highlights the importance of a balanced diet alongside GLP-1 therapy