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Challenges and future perspectives in the clinical translation of PLGA nanoparticles for PD The previously discussed preclinical studies have shown the benefits of loading drugs and natural compounds into PLGA nanoparticles to enhance therapeutic efficacy, minimize systemic toxicity, and overcome peripheral side effects associated with PD medications
We further examined nascent DNA degradation in PDS5B deficient cells expressing several RAD51 mutants, two of which (II3A and T131P) lack DNA strand exchange activity, with the remaining two (K133R and G151D) being proficient in stand exchange 36
PubMed, Esposito, Gianluca, et al
Genes Dev 33(910):511523
[10] Davies, Melanie J
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