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doi: 10.1111/acel.13037 45 VelazquezRFerreiraEWinslowWDaveNPirasISNaymikMet al

Injections may offer different absorption characteristics than oral routes, though the clinical significance is still being studied

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Engineered expression systems may not match receptor density or signaling complexity in native tissues

Traditional treatments like metformin and insulin have their limits