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Additionally, improving mitochondrial function, enhancing mitophagy, or preventing mitochondrial fragmentation could reduce mtDNA release and subsequent inflammatory signaling
Calbet & Holst (Reference Calbet and Holst63) suggested that this is because the dairy protein hydrolyses rapidly in the intestine and there is a subsequent rise in peripheral amino acids independent of the fractionation
MedComm 5:e519 Sak J, Nowiski M, Fus-Mazurkiewicz L, Mazurkiewicz W, & Krl D (2024) Effect of selenium supplementation on the development of Hashimoto thyroiditis a review of the literature
Phytotherapy Res
A 2025 study published in Obesity found that semaglutide-induced weight loss improved mitochondrial oxidative phosphorylation efficiency in skeletal muscle in mice meaning GLP-1 medications may independently support some mitochondrial improvements through weight loss itself