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Extreme deficits (800-1,000 calories below maintenance) are unnecessary and counterproductive because they increase muscle catabolism and metabolic adaptation

[427] The measure developer also found that facility performance scores in the pilot study demonstrated moderate reliability based on a signal-to-noise ratio

The main application scenarios are as follows

In rodents and in humans genetic evidence demonstrates that the loss of SIM1 causes hyperphagic obesity in addition to causing resistance to the anorectic effects of melanocortins [68,69]

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