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Notably, bile acid signaling pathways can also contribute to OA pathology, as indicated by the alleviation of murine OA after suppression of farnesoid X receptor-the receptor for the bile acid glycoursodeoxycholic acid (GUDCA), which upregulates intestinal glucagon-like peptide-1 secretion (Yang et al., 2025)

Sphingomyelin is found in cell membranes and in the fatty sheath that envelops myelinated nerve fibers

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The principle is identical

Goto A, Ishida A, Goto R, Hayasaka K, Nanao K, Yamashita A, Yamaguchi S, Takada G: Transient 5-oxoprolinuria in a very low-birthweight infant

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