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The trial, which was funded by AstraZeneca, tested different starting doses, dose-escalation schemes, and maintenance doses over a 26-week period

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Dark maroon or black stool (melena): Suggests bleeding higher up in the digestive tract, such as the stomach or small intestine

A study including 80 patients with irritable bowel syndrome and 65 healthy controls demonstrated that Ruminococcus gnavus and Lachnospiraceae species were significantly more abundant in irritable bowel syndrome (IBS)

Combine with a pinch of salt to balance the mineral ratio