Models of neuropathic pain using animals have demonstrated that GLP-1RAs have the capacity to diminish the production of pro-inflammatory cytokines such as TNF - and IL-1 , which are elevated in chronic pain conditions [74,75]
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SZ: Writing original draft
It has been reported that when ferroptosis occurs in neurons, then microglia are activated and release toxic substances including pro-inflammatory factor IL-6, which can cause neuro-inflammation and lead to further brain damage (Tang et al., 2020)