Arch Neurol 52:559564 Salamon S, Kramar B, Marolt TP, Poljsak B, Milisav I (2019) Medical and dietary uses of N-acetylcysteine
This cellular damage manifests in different signs of aging
Phase 2 trial (NEJM 2023) randomized 338 adults with obesity to retatrutide doses from 1 mg to 12 mg/week
(2024) A review of therapies for hyperpigmentation modulating the synthesis of eumelanin to pheomelanin, Archives of Dermatological Research, [online]
Without formal studies on this phenomenon, anecdotal accounts describe what appears to be accelerated skin aging rather than antiaging benefits
Patient-centred models similarly appreciate the significance of psychosocial and quality-of-life end points, such as fatigue, cognitive function, pain, emotional well-being and treatment-related nausea or neuropathy that are commonly endorsed by patients in explaining their motivation to take supplements (236)