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The kidneys and liver are particularly vulnerable to senescent cell accumulation because of their high metabolic activity and constant exposure to circulating toxins

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Despite the lack of extra support for lifestyle modification as part of the SURPASS program, 4069% of patients achieved 10% weight loss with the highest doses of tirzepatide (1015 mg), which ranged from 9.5 kg to 12.9 kg [100]

However, controlled human trials evaluating these effects are lacking

They seek products that deliver visible, evidence-based changes