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men was similar (hazard ratio, 0.66 and 0.61, respectively, interaction p=0.81)

RNAscope validation of Gipr deletion in trigeminal ganglion of 44-week old male chow-fed WT and KO mice (q) and of the DRG of 51-week old male chow-fed WT and KO mice (r)

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It activates the Nrf2 pathway, a master regulator that upregulates multiple antioxidant enzymes simultaneously, creating a comprehensive antioxidant response

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Studies examining safety and tolerability in rodents have generally not reported concerning toxicity signals at doses producing metabolic benefits, though comprehensive toxicology studies and long-term safety data are limited