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When insulin sensitivity improves, patients typically notice: * fewer cravings * more stable energy * better appetite regulation * easier weight maintenance * improved metabolic flexibility 2

Despite the link, the role of insulin abnormalities in PD remains contentious, with little difference found between patients with PD and healthy controls in peripheral insulin resistance, quantified using a hyperinsulinemic-euglycemic clamp [71]

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Orforglipron, Lilly's once-daily oral non-peptide GLP-1 agonist, helped overweight adults without diabetes lose 12.4% of their body weight over 72 weeks at the highest dose in a late-stage trial