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doi: 10.1055/s-2007-978671 14 DiamondFJEichlerDC

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officinale could inhibit inflammatory mediators of COX-2 with IC 50 values of 32, 7.5, and 17.5 M, respectively, but there is no inhibitory activity reported in COX-1

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This modulation influenced microbial metabolism and peripheral inflammation, regulated the activation state and functionality of microglia, and thereby reduced neuroinflammation and amyloidosis