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The October 2025 analysis published in the Journal of the Endocrine Society (abstract SUN-659, with full peer-reviewed article at PMC12544991) reported retatrutide at a mean absolute reduction of 16.34 kg and 23.77% body weight versus 11.82 kg and 16.79% for tirzepatide, an indirect advantage in retatrutides favour 20

Importantly, the trials acquired no amyloid or tau PET, or mechanistic PET/synaptic imaging

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