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Warnings and Precautions 5.1 Risk of Thyroid C-Cell Tumors In both sexes of rats, tirzepatide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) in a 2-year study at clinically relevant plasma exposures [see Nonclinical Toxicology (13.1)]

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Weekly Schedule For the standard Wolverine Stack, the most commonly used structure across the dataset is: Weeks 1 to 4 (Loading) Weeks 5 to 12 (Maintenance) If a dose was missed, the advice is to dose the next day, not double up