A variation in blood glucose is linked with the exaggeration of systematic inflammation, even in patients without diabetes (Al-kuraishy et al
2024;326:E26876
Severe or recurrent genital mycotic infections and urinary tract infections warrant treatment suspension if they become problematic ( Canagliflozin specifically should be discontinued in patients with a heightened risk of amputations, including those with a history of amputations, severe peripheral neuropathy, severe peripheral arterial disease, or active lower-limb ulcers or infections, as well as in individuals with an increased fracture risk, particularly those with previous osteoporotic fractures ( 3.3 Mechanism of action of GLP1 receptor agonists GLP-1 is a hormone belonging to the incretins that is produced in the gastrointestinal tract, by L cells, in response to the intake of nutrients, especially fat and glucose ( GLP-1 RAs like liraglutide and semaglutide, offer a therapeutic advantage over native GLP-1 by being resistant to degradation by dipeptidyl peptidase-4 (DPP-4)

To prevent hypokalemia, regular blood tests to monitor potassium levels are beneficial, especially if youre taking semaglutide and other medications that affect electrolytes
Ozempic can help people with obesity or overweight lose weight
Consensus Statement on Obesity Management