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The introduction of the dual-effector theory in 1985 disputed the original somatomedin hypothesis and proposed an additional IGF-1-independent role of GH [141]

Studies have shown that people with low levels of glutathione are more likely to experience alcohol-related health problems, such as liver damage and alcoholic hepatitis

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5 Conclusion UA is a beneficial natural metabolite endogenously produced in the human body

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Inhibition of CYP450 enzyme activity and activation of the Nrf2 signaling pathway and GSH synthesis are two intriguing targets for the treatment of acute liver injury caused by APAP