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However, like many polymeric carriers, their intrinsic ability to cross the BBB is limited without functional modification

A growing body of research in behavioral neuroscience and neuroendocrinology positions sleep optimization as one of the highest-leverage interventions for healthy aging

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By inhibiting NNMT, it alters the balance of S-adenosylmethionine (SAM) and nicotinamide metabolism, affecting DNA methylation patterns and histone modifications

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