Once activated, these receptors turn key signaling proteins up or down, including GLP-1, ghrelin, CCK, and GIP, which together influence appetite, blood sugar, and fat metabolism
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Other risk factors that may increase vulnerability include: Long duration of diabetes (typically more than 10 years) Poor glycaemic control prior to starting GLP-1 therapy (HbA1c significantly above target) Rapid reduction in HbA1c (a drop of more than 2 percentage points [22 mmol/mol] within 36 months) Concurrent hypertension , especially if poorly controlled Diabetic kidney disease (nephropathy), which often correlates with retinopathy severity Previous history of retinal treatment (laser photocoagulation or intravitreal injections) People with type 2 diabetes but no retinopathy appear to have minimal risk of retinopathy progression based on current evidence
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10.1152/physrev.00023.2017 Physiol Rev
Invest Ophthalmol Vis Sci 55(12):81739 Thaller M et al (2023) The idiopathic intracranial hypertension prospective cohort study: evaluation of prognostic factors and outcomes
