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Among these systems, glutathione (GSH) peroxidase 4 (GPX4) plays a dominant role by converting LOOH into nontoxic lipid alcohols (LOH) using GSH as an electron donor 10

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Of note, Atg5/Atg7-dependent macroautophagy occurs predominantly at the level of early erythroblasts with mitophagy taking place during further erythroblast differentiation [56]

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The lower promoter methylation of GPX1, a member of the GPX family that interact with oxidative stress, results in high expression levels of GPX1 in some cancer cell lines (Wei R