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Our findings confirm that longer diabetes duration is associated with a lower glycaemic response to GLP-1 RAs [3, 6, 16], probably due to declining beta cell function, as intact insulin secretion is necessary for a robust glycaemic response to this drug class [1, 3]

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Lastly, some common side effects of Ozempic are nausea and vomiting, both of which can kill a persons appetite

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I barely scratched the surface, but I think I gave you the essence of it