Buscema, P
Risk factors that should prompt consideration of B12 deficiency include advancing age (reduced stomach acid production), strict vegan or vegetarian diets, pernicious anaemia, gastrointestinal surgery (particularly gastric bypass or ileal resection), long-term use of certain medications (metformin, proton pump inhibitors, H2-receptor antagonists), nitrous oxide exposure (including recreational use), and conditions affecting the gut such as Crohn's disease or coeliac disease
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2023) which reported raised PI3K and AKT levels in a rat model of AA-induced colitis and a recent study which discovered that acute AA-induced colitis in rats contributed to an upregulation of PI3K and AKT (Xu et al
Redundant mechanism, doubled GI side effects