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Retatrutide remains investigational, with Phase 3 trials ongoing and potential approval not expected until mid-2026 or 2027 at the earliest

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Several studies have shown that mega doses of the vitamin can lead to outbreaks of acne and rosacea which is a skin condition that causes redness and pus-filled bumps on the face

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In 2015, another double-blind RCT reported significant improvements in pain associated with aphthous ulcers with a B12 ointment compared with a B12-free ointment

Registered Phase 1 Study ClinicalTrials.gov contains a Phase 1 record registered under NCT02637284