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PMID 12055211 "Mechano-growth factor: a splice variant of IGF-1 induced by mechanical loading." ( Journal of Physiology , 2002)

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PD-1 regulates KLRG1(+) group 2 innate lymphoid cells

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Without sufficient levels, your cells are left vulnerable to the "rusting" process of oxidation, which contributes to visible signs of aging and a decline in overall vitality