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The liver filters out most of the B12 but provides a constant stream in the blood to the rest of the body

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19 Early studies: There were studies in the 1950s and the1960s that showed that oral vitamin B 12 could be absorbed by patients with pernicious anemia and could lead to resolution of the anemia

Manganese has a role in Protein metabolism, disease resistance, bone and cartilage and connective tissue development, reproduction/fertility, ovulation, spermatogenesis and embryo survival

In fact some research suggests that B12 analogues may compete with B12 leading to the metabolism being inhibited

doi:10.1002/14651858.CD003678.pub3