On the other hand, strict glucose control does not limit or improve the damage caused by diabetes and its comorbidities to the CNS [17, 18] as the impact of insulin resistance, obesity, and diabetes on the CNS begins very early in the natural history of the disease [19]
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Substantial preclinical and clinical research over the years corroborated the cardiovascular benefits of GLP-1RAs, which are primarily linked to their role in alleviating atherosclerosis by managing associated risk factors [9]
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Wearing loose clothing can prevent further irritation, and dont forget to rotate your injection sites
If dietary measures are insufficient, over-the-counter fiber supplements (psyllium, methylcellulose) or osmotic laxatives (polyethylene glycol) may be appropriate after discussing with your healthcare provider