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In a randomised controlled trial with over 1800 participants comparing tirzepatide to semaglutide, the tirzepatide group reported more serious adverse events (5-7% VS 3%) and higher discontinuation rates due to adverse events (6-8.5% VS 4%)

Because these drugs essentially act as hormones (which, once metabolized, lose their efficacy), this drop in adherence may not bode well for maintaining the effects of these drugs in the long term

Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity

Frequently asked questions about GLP-1 timing What happens if I miss my normal dosage time

Wang, J

To minimize side effects and support weight loss, consider these guidelines: Avoid fatty, fried, high-sugar, and unhealthy fast foods Limit alcohol consumption Stay hydrated by drinking plenty of water What are the side effects of GLP-1/GIP