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Indole derivatives can modulate the activity of microglia and astrocytes, thus reducing the production of proinflammatory cytokines

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It also provides additional benefit to neurons by providing some protection from inadequate oxygen and blood supplies, which may occur in the case of an injury

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Real-time quantitative polymerase chain reaction Total RNA was extracted from cells using the Trizol reagent (Takara Bio Inc, Japan) according to the manufacturers instructions

10.1016/j.fct.2015.02.011 Food Chem Toxicol