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Pernicious anaemia is caused by a deficiency in vitamin B12, due to atrophic gastritis, an autoimmune condition (immune system destroys self), in this case the parietal cells of the stomach that produce intrinsic factor, a glycoprotein that binds to vitamin B12 in the stomach and is essential for normal absorption of vitamin B12 in the small intestine into the blood

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Demand had so thoroughly outpaced manufacturing capacity that continuity of care for people with type 2 diabetes was at risk and prescribers were urged not to initiate GLP-1 therapies outside their approved indications while constraints remained in place

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The expected impact of GLP-1 receptor agonists inhibitors on decreasing BMI, FM, VFA, and BFR was verified in this meta-analysis, consistent with the results of prior meta-analyses