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If semaglutide was unrefrigerated for more than 30 minutes before first use, discard it

NICE guidance for NHS provision is more restrictive, recommending Wegovy only for people with: BMI of 35 kg/m or greater, or BMI of 3034.9 kg/m with at least one weight-related comorbidity, and Participation in a specialist weight management service For a maximum treatment duration of 2 years Additionally, clinicians should consider discontinuing treatment if patients do not achieve adequate weight loss, following local protocols and clinical judgement

Endocrinology 156 , 847857 (2015)

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However, this only applies if Wegovy is prescribed through NHS services

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