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Modified from Tschop et al

GLP-1 improves insulin sensitivity and lowers blood glucose levels, making it an essential treatment option for people with uncontrolled type 2 diabetes

The liver zonation model was implemented in Python (ver.3.10, with NumPy library (ver

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Signaling pathways in immunosenescence Aberrant activation of various signaling pathways, including but not limited to the NF-B, mTOR, JAK-STAT, cGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon genes), AMPK (AMP-activated protein kinase), melatonin, and sirtuin pathways, plays a crucial role in regulating immune function during aging

This serves as a proxy to assess whether the binder could attain the designed structure by itself, which we use to filter out designs that are likely to require a significant conformational change upon binding or do not express since they do not fold into a stable structure by themselves